Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

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Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery

A spirocyclic, sp3-atom rich oxetane-containing scaffold was synthesised in just two steps via a gold catalysed propargylic alcohol rearrangement. The key gold cyclisation can be undertaken on a 40 g scale allowing the preparation of 419 lead-like compounds based on the scaffold for the European Lea...

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Bibliographic Details
Main Authors:	Geary, Gemma C., Nortcliffe, Andrew, Pearce, Christopher A., Hamza, Daniel, Jones, Geraint, Moody, Christopher J.
Format:	Article
Published:	Elsevier 2017
Online Access:	https://eprints.nottingham.ac.uk/49828/

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