Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding

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Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding

DNA-based drug delivery vehicles have displayed promise for the delivery of intercalating drugs. Here, we demonstrate that oligonucleotides modified with an alkyl chain can bind to human serum albumin, mimicking the natural binding of fatty acids. These alkyl-DNA-albumin complexes display excellent...

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Bibliographic Details
Main Authors:	Purdie, Laura, Alexander, Cameron, Spain, Sebastian G., Magnusson, Johannes P.
Format:	Article
Published:	American Chemical Society 2018
Subjects:	Oligonucleotides Albumin Cytotoxic Prodrug. Mitochondrial targeting
Online Access:	https://eprints.nottingham.ac.uk/49816/

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