Alkyl-modified oligonucleotides as intercalating vehicles for doxorubicin uptake via albumin binding
DNA-based drug delivery vehicles have displayed promise for the delivery of intercalating drugs. Here, we demonstrate that oligonucleotides modified with an alkyl chain can bind to human serum albumin, mimicking the natural binding of fatty acids. These alkyl-DNA-albumin complexes display excellent...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
American Chemical Society
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/49816/ |