Citrullinated vimentin presented on MHC-II in tumor cells is a target for CD4+ T-cell-mediated antitumor immunity
Stressful conditions in the harsh tumor microenvironment induce autophagy in cancer cells as a mechanism to promote their survival. However, autophagy also causes post-translational modification of proteins that are recognized by the immune system. In particular, modified self-antigens can trigger C...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
American Association for Cancer Research
2016
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| Online Access: | https://eprints.nottingham.ac.uk/49781/ |