N_LyST: a simple and rapid screening test for Lynch Syndrome

QR Code

N_LyST: a simple and rapid screening test for Lynch Syndrome

Aims: We sought to use PCR followed by high-resolution melting (HRM) analysis to develop a single closed-tube screening panel to screen for Lynch Syndrome. This comprises tests for microsatellite instability (MSI), MLH1 methylation promoter and BRAF mutation. Methods:For MSI-testing, 5 mononucleoti...

Full description

Bibliographic Details
Main Authors:	Susanti, Susanti, Fadhil, Wakkas, Ebili, Henry O., Asiri, Abutaleb, Nestarenkaite, Ausrine, Hadjimichael, Efthymios, Ham-Karim, Hersh A., Field, Joanne, Stafford, Katherine, Matharoo-Ball, Balwir, Hassall, James C., Sharif, Abid, Oniscu, Anca, Ilyas, Mohammad
Format:	Article
Published:	BMJ Publishing Group Ltd 2018
Subjects:	Microsatellite Instability (MSI); High Resolution Melting (HRM); Colorectal cancer; Lynch Syndrome; BRAF mutation; Promoter methylation
Online Access:	https://eprints.nottingham.ac.uk/49611/

Similar Items

An investigation of metastatic colorectal cancer
by: Asiri, Abutaleb
Published: (2018)

Adam`s Genealogy (LY)
by: Yaacob, Solehah@Nik Najah Fadilah
Published: (2020)

Costs and outcomes of Lynch syndrome screening in the Australian colorectal cancer population
by: Cenin, Dayna, et al.
Published: (2018)

Chai Ly Min dinobat Anugerah Kecemerlangan Telekom
by: Shalfarina, Shahriman
Published: (2019)

Investigate tumour heterogeneity and genetic pathways in colorectal cancer
by: Ham Karim, Hersh Abdul
Published: (2017)

Performance of telecommunications industry in the wake of liberalisation: the case of Tanzania Telecommunications Company Limited
by: Kasanga, Edwin Ibrahim Kikuli
Published: (2005)

Population-based detection of lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test
by: Sehofield, L., et al.
Published: (2009)

The impact of temperature fluctuations on the large-scale clustering of the Lyα forest
by: Greig, Bradley, et al.
Published: (2015)

Diagnosing galactic feedback with line broadening in the low redshift Lyα forest
by: Viel, Matteo, et al.
Published: (2017)

Investigating barriers to genetic counseling and germline mutation testing in women with suspected hereditary breast and ovarian cancer syndrome and Lynch syndrome
by: Shaw, J., et al.
Published: (2018)

LY2495655, an antimyostatin antibody in pancreatic cancer: a randomized phase 2 trial
by: Golan, Talia, et al.
Published: (2018)

"A West Indian? You must be joking! I come out of the East End": Kenny Lynch and English racism in the 1950s and 1960s
by: Stratton, Jon
Published: (2009)

'A West Indian? You must be joking! I come out of the East End': Kenny Lynch and English racism in the 1950's and 1960s'
by: Stratton, Jon
Published: (2012)

A genre analysis of formula milk pamphlets and sample boxes / Delicia Ng Ly-Ann
by: Ng, Delicia Ly-Ann
Published: (2015)

Evidence of patchy hydrogen reionization from an extreme Lyα trough below redshift six
by: Becker, George D., et al.
Published: (2015)

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
by: Shi, Y., et al.
Published: (2013)

Technology Entrepreneurship: Ingenious.Ly Sdn. Bhd. / Nur Liana Mohd Rashid… [et al.]
by: Mohd Rashid, Nur Liana, et al.
Published: (2020)

Survey parameters for detecting 21-cm-Ly a emitter cross-correlations with the Square Kilometre Array
by: Hutter, A., et al.
Published: (2018)

Adaptive responses as mechanisms of resistance to braf inhibitors in melanoma
by: Saei, A., et al.
Published: (2019)

SHARDS frontier fields: physical properties of a low-mass Lyα emitter at z = 5.75
by: Hernán-Caballero, Antonio, et al.
Published: (2017)

The tributary relations between China’s Song Dynasty and Vietnam’s Dinh, Le and Ly Dynasties: Effects on their political sustainability
by: Ku, Boon Dar
Published: (2019)

The Tributary Relations between China’s Song Dynasty and Vietnam’s Dinh, Le and Ly Dynasties: Effects on Their Political Sustainability
by: Ku, Boon Dar
Published: (2019)

From Silenced Victims To National Heroines : Acts Of Impersonation In Narratives Of Le Ly Hayslip And Nora Okja Keller
by: Chow, Sheat Fun
Published: (2012)

Investigating the interactions between tumour cells and the non-tumour cellular community in colorectal cancer
by: Susanti, Susanti
Published: (2021)

IGM constraints from the SDSS-III/BOSS DR9 Lyα forest transmission probability distribution function
by: Lee, K.-G., et al.
Published: (2015)

Effect of salinity on growth and cytotoxicity of extracts from a marine-derived Penicillium sp.(LY1L5).
by: Mahyudin, Nor Ainy

Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511
by: Tucker-Kellogg, L., et al.
Published: (2012)

Sequence analysis of the fusion(F) and matrix(M) genes of recen1ly isolated New Castle disease virus from Malaysia
by: Tan, Sheau Wei, et al.
Published: (2005)

Contemporary use of co-design and computational design methods for inclusive built environments: a case study of platform-train interfaces
by: Kapsalis, Efthymios Timo
Published: (2024)

Interrogating the genetic profile of sporadic colorectal cancer
by: Fadhil, Wakkas M.
Published: (2019)

Altered object exploration but not temporal order memory retrieval in an object recognition test following treatment of rats with the group II metabotropic glutamate receptor agonist LY379268
by: Lins, Brittney, et al.
Published: (2014)

Entrepreneurial Failue: A Cognitive and Emotional Perspective of Learning
by: Anca, Cristiana
Published: (2007)

A flood management strategy for the Harvey River
by: Yusman, Ana Susanti
Published: (2009)

Tax knowledge, tax ethics and tax non compliant behavior of non-accounting postgraduates from Universiti Teknologi MARA (UiTM), Shah Alam / Mira Susanti Amirrudin
by: Amirrudin, Mira Susanti
Published: (2007)

Students’ perceptions towards peer feedback approach in a Malaysian English as a Second Language (ESL) classroom / Misyana Susanti Husin and Kamisah Hj Ariffin
by: Husin, Misyana Susanti
Published: (2008)

Introduction
by: Darnis, Deny Susanti
Published: (2011)

Biological activity of natural products
by: Darnis, Deny Susanti
Published: (2011)

Standardization process and plant metabolomics in natural products research
by: Darnis, Deny Susanti
Published: (2011)

Research in natural products
by: Darnis, Deny Susanti
Published: (2011)

Methods in natural products research
by: Darnis, Deny Susanti
Published: (2011)