N_LyST: a simple and rapid screening test for Lynch Syndrome

N_LyST: a simple and rapid screening test for Lynch Syndrome

Aims: We sought to use PCR followed by high-resolution melting (HRM) analysis to develop a single closed-tube screening panel to screen for Lynch Syndrome. This comprises tests for microsatellite instability (MSI), MLH1 methylation promoter and BRAF mutation. Methods:For MSI-testing, 5 mononucleoti...

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Bibliographic Details
Main Authors: Susanti, Susanti, Fadhil, Wakkas, Ebili, Henry O., Asiri, Abutaleb, Nestarenkaite, Ausrine, Hadjimichael, Efthymios, Ham-Karim, Hersh A., Field, Joanne, Stafford, Katherine, Matharoo-Ball, Balwir, Hassall, James C., Sharif, Abid, Oniscu, Anca, Ilyas, Mohammad
Format: Article
Published: BMJ Publishing Group Ltd 2018
Subjects:
Microsatellite Instability (MSI); High Resolution Melting (HRM); Colorectal cancer; Lynch Syndrome; BRAF mutation; Promoter methylation
Online Access:https://eprints.nottingham.ac.uk/49611/

Internet

https://eprints.nottingham.ac.uk/49611/

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