Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance

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Increasing cardiac pyruvate dehydrogenase flux during chronic hypoxia improves acute hypoxic tolerance

The pattern of metabolic reprogramming in chronic hypoxia shares similarities with that following myocardial infarction or hypertrophy, however the response of the chronically hypoxic heart to subsequent acute injury, and the role of metabolism is not well understood. Here, we determined the myocard...

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Bibliographic Details
Main Authors:	Handzlik, Michal, Constantin-Teodosiu, Dumitru, Greenhaff, Paul L., Cole, Mark
Format:	Article
Published:	Wiley 2018
Subjects:	Heart Hypoxia Metabolism Pyruvate Dehydrogenase Complex
Online Access:	https://eprints.nottingham.ac.uk/49461/

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