Synthetic glycopolymers as modulators of protein aggregation: influence of chemical composition, topology and concentration

QR Code

Synthetic glycopolymers as modulators of protein aggregation: influence of chemical composition, topology and concentration

Novel drug excipients are required to achieve stable formulations of protein drug candidates. Synthetic glycopolymers have been shown in some cases to improve protein formulation stability, although their structure function relationship remains unknown. Here we report the synthesis of linear or 4-ar...

Full description

Bibliographic Details
Main Authors:	Madeira do Ó, João, Mastrotto, Francesca, Francini, Nora, Allen, Stephanie, van der Walle, Christopher, Stolnik, Snow, Mantovani, Giuseppe
Format:	Article
Published:	Royal Society of Chemistry 2018
Online Access:	https://eprints.nottingham.ac.uk/49364/

Similar Items

Applications of glycopolymer libraries as protein aggregation modulators and drug delivery systems
by: Madeira do Ó, João
Published: (2016)

Phosphonium polymers for gene delivery
by: Loczenski Rose, Vanessa, et al.
Published: (2016)

A spoonful of sugar: the application of glycopolymers in therapeutics
by: Spain, Sebastian G., et al.
Published: (2011)

Glycopolymer-based materials : Synthesis, properties, and biosensing applications
by: Thalji, Mohammad R., et al.
Published: (2022)

Effect of polymer topology on non-covalent polymer-protein complexation: miktoarm versus linear mPEG-poly(glutamic acid) copolymers
by: Nieto-Orellana, Alejandro, et al.
Published: (2017)

Multifunctional poly[N-(2-hydroxypropyl)methacrylamide] copolymers via postpolymerization modification and sequential thiol–ene chemistry
by: Francini, Nora, et al.
Published: (2015)

Biosynthesis of Chiral Poly-Hydroxyacyl Esters and their Enzymatic Functionalization as Glycopolymers / Ahmad Mohammed Gumel
by: Gumel, Ahmad Mohammed
Published: (2013)

Quantum topology and the Lorentz group
by: Martins, João Nuno Gonçalves Faria
Published: (2004)

Polymers for binding of the gram-positive oral pathogen Streptococcus mutans
by: Magennis, Eugene Peter, et al.
Published: (2017)

Sugar-coated nanoparticles: Investigating lipid-terminated glycopolymers for targeted nanoparticle delivery of nucleic acids
by: Fiedler, Benjamin
Published: (2024)

Synthetic Lightweight Coarse Aggregate using Offshore Sand
by: Mohammad Amirulkhairi, Zubir, et al.
Published: (2015)

Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA
by: Capel, Victoria, et al.
Published: (2018)

Dry-powder formulations of non-covalent protein complexes with linear or miktoarm copolymers for pulmonary delivery
by: Nieto-Orellana, Alejandro, et al.
Published: (2018)

Aggregation Prone Region analogues: synthetic excipients for protein formulation
by: Foralosso, Ruggero
Published: (2019)

Enhanced uptake in 2D- and 3D- lung cancer cell models of redox responsive PEGylated nanoparticles with sensitivity to reducing extra-and intracellular environments
by: Conte, Claudia, et al.
Published: (2018)

Mechanical properties of synthetic lightweight coarse aggregate infuse with offshore sand
by: Mohammad Amirulkhairi, Zubir, et al.
Published: (2022)

Flexural behaviour of reinforced synthetic lightweight coarse aggregate (SYLCAG) concrete
by: Mohd Zawawiv, Aziz
Published: (2014)

Mechanical properties of concrete using synthetic lighweight coarse aggregate (SYLCAG)
by: Mohd Fairuz, Azmi
Published: (2014)

Recycled concrete aggregates as a filter for removal of phosphorus in synthetic wastewater
by: Abd Roni, Norwardatun, et al.
Published: (2018)

Performance of asphalt mixtures containing steel slag aggregate and synthetic fibers
by: Hezam Alnadish, Adham Mohammed
Published: (2019)

The performance of concrete using synthetic lightweight coarse aggregate (SYLCAG) on flexural behavior
by: Siti Nur Amira, Hassan
Published: (2015)

Synthetic lighweight coarse aggregate (SYLCAG) concrete using artificial offshore sand
by: Muhammad Nazrin Akmal, Ahmad Zawawi
Published: (2014)

Study of recycled concrete aggregate as filter media for phosphorus removal in synthetic wastewater
by: Abd Roni, Norwardatun
Published: (2019)

Insight into the relationship between the cell culture model, cell trafficking and siRNA silencing efficiency
by: Capel, Victoria, et al.
Published: (2016)

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells
by: Alshehri, Abdullah Ali, et al.
Published: (2018)

On topological dimension
by: Azram, Mohammad
Published: (2009)

Topological Dimension
by: Azram, Mohammad
Published: (2010)

Flexural behaviour of reinforced concrete beam using partial synthetic lightweight coarse aggregate (SYLCAG)
by: Siti Fatimah, Mohamed Salleh
Published: (2015)

Removal of phosphorus from synthetic wastewater using recycled concrete aggregates as a filter medium
by: ‪Adnan, Suraya Hani‬, et al.
Published: (2018)

Removal of phosphorus from synthetic wastewater using recycled concrete aggregates as a filter medium
by: Adnan, S. H., et al.
Published: (2018)

Kinetic Aggregation And Settling Properties Of Silicon Dioxide Nanoparticles In Chemical Mechanical Polishing Synthetic Wastewater
by: Azman, Nur Athirah Nor
Published: (2022)

The efficacy of recycled concrete aggregate for removal phosphorus in synthetic wastewater with different pH value
by: Adnan, Suraya Hani, et al.
Published: (2020)

One-pot RAFT and fast polymersomes assembly: a ‘beeline’ from monomers to drug-loaded nanovectors
by: Mastrotto, Francesca, et al.
Published: (2016)

Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells
by: Brazzale, C., et al.
Published: (2017)

Concentration-dependent aggregation behavior of asymmetric cationic surfactant hexyldimethyloctylammonium bromide
by: Hyde, A., et al.
Published: (2017)

Measure, topology, and compactness
by: Ganikhodjaev, Nasir
Published: (2017)

An electrochemical system for the study of trans-plasma membrane electron transport in whole eukaryotic cells
by: Sherman, Harry G., et al.
Published: (2018)

Control of aggregation temperatures in mixed and blended cytocompatible thermoresponsive block co-polymer nanoparticles
by: Foralosso, Ruggero, et al.
Published: (2017)

The role of copper(II) in the aggregation of human amylin
by: Sinopoli, Alessandro, et al.
Published: (2014)

PLGA microcapsules with novel dimpled surfaces for pulmonary delivery of DNA
by: Mohamed, Farahidah, et al.
Published: (2006)