Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells

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Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells

The efficacy of temozolomide (TMZ) treatment for cancers is currently limited by inherent or the development of resistance, particularly, but not exclusively, due to the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) in a significant proportion of tumours. We have...

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Bibliographic Details
Main Authors:	Yang, Zhikuan, Wei, Danping, Liu, Feifei, Liu, Jing, Wu, Xiaoming, Stevens, Malcolm F. G., Bradshaw, Tracey D., Luo, Ying, Zhang, Jihong
Format:	Article
Published:	Wiley 2018
Subjects:	PMX 465 ; O6-methylguanine-DNA methyltransferase ; p53 ; Sp1 ; Colorectal carcinoma
Online Access:	https://eprints.nottingham.ac.uk/49220/

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