Temozolomide analog PMX 465 downregulates MGMT expression in HCT116 colorectal carcinoma cells
The efficacy of temozolomide (TMZ) treatment for cancers is currently limited by inherent or the development of resistance, particularly, but not exclusively, due to the expression of the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) in a significant proportion of tumours. We have...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Published: |
Wiley
2018
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/49220/ |