Predicting effective pro-apoptotic antileukaemic drug combinations using cooperative dynamic BH3 profiling

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Predicting effective pro-apoptotic antileukaemic drug combinations using cooperative dynamic BH3 profiling

The BH3-only apoptosis agonists BAD and NOXA target BCL-2 and MCL-1 respectively and co-operate to induce apoptosis. On this basis, therapeutic drugs targeting BCL-2 and MCL-1 might have enhanced activity if used in combination. We identified anti-leukaemic drugs sensitising to BCL-2 antagonism and...

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Bibliographic Details
Main Authors:	Grundy, Martin, Seedhouse, Claire, Jones, Thomas, Elmi, Liban, Hall, Michael, Graham, Adam, Russell, Nigel, Pallis, Monica
Format:	Article
Published:	Public Library of Science 2018
Online Access:	https://eprints.nottingham.ac.uk/48961/

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