Predicting effective pro-apoptotic antileukaemic drug combinations using cooperative dynamic BH3 profiling
The BH3-only apoptosis agonists BAD and NOXA target BCL-2 and MCL-1 respectively and co-operate to induce apoptosis. On this basis, therapeutic drugs targeting BCL-2 and MCL-1 might have enhanced activity if used in combination. We identified anti-leukaemic drugs sensitising to BCL-2 antagonism and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Public Library of Science
2018
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| Online Access: | https://eprints.nottingham.ac.uk/48961/ |