Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development

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Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development

TBX5 plays a critical role in heart and forelimb development. Mutations in TBX5 cause Holt-Oram syndrome, an autosomal dominant condition that affects the formation of the heart and upper - limb. Several studies have provided significant insight into the role of TBX5 in cardiogenesis; however, how...

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Bibliographic Details
Main Authors:	Ghosh, Tushar K., Aparicio-Sánchez, José J., Buxton, Sarah, Ketley, Ami, Mohamed, Tasabeeh, Rutland, Catrin S., Loughna, Siobhan, Brook, J. David
Format:	Article
Published:	Elsevier 2018
Subjects:	TBX5 acetylation heart development CRISPR-Cas zebrafish
Online Access:	https://eprints.nottingham.ac.uk/48810/

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