Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology

Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology

Human induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) have applications in disease modeling, cell therapy, drug screening and personalized medicine. Computational models can be used to interpret experimental findings in iPSC-CMs, provide mechanistic insights, and translate these find...

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Bibliographic Details
Main Authors: Lei, Chon-Lok, Wang, Ken, Clerx, Michael, Johnstone, Ross H., Hortigon-Vinagre, Maria P., Zamora, Victor, Allan, Andrew, Smith, Godfrey L., Gavaghan, David J., Mirams, Gary R., Polonchuk, Liudmila
Format: Article
Published: Frontiers Research Foundation 2017
Subjects:
cardiomyocytes
stem cell derived
electrophysiology
mathematical model
pharmacology
variability
computational model
Online Access:https://eprints.nottingham.ac.uk/48668/

Internet

https://eprints.nottingham.ac.uk/48668/

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