Cancer chemotherapy in early life significantly alters the maturation of pain processing
Advances in paediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g.cisplatin) induce peripheral sensory neuropathy in adult and paedriatric cancer patients. The period from birth through to adulthood represents a period of maturation wit...
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/48459/ |
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| author | Hathway, Gareth J. Murphy, Emily Lloyd, Joseph Greenspon, Charles M. Hulse, Richard P. |
| author_facet | Hathway, Gareth J. Murphy, Emily Lloyd, Joseph Greenspon, Charles M. Hulse, Richard P. |
| author_sort | Hathway, Gareth J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Advances in paediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g.cisplatin) induce peripheral sensory neuropathy in adult and paedriatric cancer patients. The period from birth through to adulthood represents a period of maturation within nociceptive systems. Here we investigated how cisplatin impacts upon postnatal maturation of nociceptive systems. Neonatal Wistar rats (Postnatal day (P) 7) were injected (i.p.) daily with either vehicle (PBS) or cisplatin (1mg/kg) for five consecutive days. Neither group developed mechanical or thermal hypersensitivity immediately during or after treatment. At P22 the cisplatin group developed mechanical (P<0.05) and thermal (P<0.0001) hypersensitivity versus vehicle group. Total DRG or dorsal horn neuronal number did not differ at P45, however there was an increase in intraepidermal nerve fibre density in cisplatin treated animals at this age. The percentage of IB4+ve, CGRP+ve and NF200+ve DRG neurons was not different between groups at P45. There was an increase in TrkA+ve DRG neurons in the cisplatin group at P45, in addition to increased TrkA, NF200 and vGLUT2 immunoreactivity in the lumbar dorsal horn versus controls. These data highlight the impact paediatric cancer chemotherapy has upon the maturation of pain pathways and later life pain experience. |
| first_indexed | 2025-11-14T20:09:07Z |
| format | Article |
| id | nottingham-48459 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:09:07Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-484592024-08-15T15:25:29Z https://eprints.nottingham.ac.uk/48459/ Cancer chemotherapy in early life significantly alters the maturation of pain processing Hathway, Gareth J. Murphy, Emily Lloyd, Joseph Greenspon, Charles M. Hulse, Richard P. Advances in paediatric cancer treatment have led to a ten year survival rate greater than 75%. Platinum-based chemotherapies (e.g.cisplatin) induce peripheral sensory neuropathy in adult and paedriatric cancer patients. The period from birth through to adulthood represents a period of maturation within nociceptive systems. Here we investigated how cisplatin impacts upon postnatal maturation of nociceptive systems. Neonatal Wistar rats (Postnatal day (P) 7) were injected (i.p.) daily with either vehicle (PBS) or cisplatin (1mg/kg) for five consecutive days. Neither group developed mechanical or thermal hypersensitivity immediately during or after treatment. At P22 the cisplatin group developed mechanical (P<0.05) and thermal (P<0.0001) hypersensitivity versus vehicle group. Total DRG or dorsal horn neuronal number did not differ at P45, however there was an increase in intraepidermal nerve fibre density in cisplatin treated animals at this age. The percentage of IB4+ve, CGRP+ve and NF200+ve DRG neurons was not different between groups at P45. There was an increase in TrkA+ve DRG neurons in the cisplatin group at P45, in addition to increased TrkA, NF200 and vGLUT2 immunoreactivity in the lumbar dorsal horn versus controls. These data highlight the impact paediatric cancer chemotherapy has upon the maturation of pain pathways and later life pain experience. Elsevier 2017-12-02 Article PeerReviewed Hathway, Gareth J., Murphy, Emily, Lloyd, Joseph, Greenspon, Charles M. and Hulse, Richard P. (2017) Cancer chemotherapy in early life significantly alters the maturation of pain processing. Neuroscience . ISSN 1873-7544 (In Press) cisplatin; neuropathy; pain; hyperalgesia; development; postnatal https://www.sciencedirect.com/science/article/pii/S0306452217308266 doi:10.1016/j.neuroscience.2017.11.032 doi:10.1016/j.neuroscience.2017.11.032 |
| spellingShingle | cisplatin; neuropathy; pain; hyperalgesia; development; postnatal Hathway, Gareth J. Murphy, Emily Lloyd, Joseph Greenspon, Charles M. Hulse, Richard P. Cancer chemotherapy in early life significantly alters the maturation of pain processing |
| title | Cancer chemotherapy in early life significantly alters the maturation of pain processing |
| title_full | Cancer chemotherapy in early life significantly alters the maturation of pain processing |
| title_fullStr | Cancer chemotherapy in early life significantly alters the maturation of pain processing |
| title_full_unstemmed | Cancer chemotherapy in early life significantly alters the maturation of pain processing |
| title_short | Cancer chemotherapy in early life significantly alters the maturation of pain processing |
| title_sort | cancer chemotherapy in early life significantly alters the maturation of pain processing |
| topic | cisplatin; neuropathy; pain; hyperalgesia; development; postnatal |
| url | https://eprints.nottingham.ac.uk/48459/ https://eprints.nottingham.ac.uk/48459/ https://eprints.nottingham.ac.uk/48459/ |