NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy

NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy

NAD metabolism and the NAD biosynthetic enzymes nicotinamide nucleotide adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in tauopathies, including Alzheimer’s disease. Here, we investigated whether modulating the expression of the NMNAT nuclear isoform NMNAT1, which is im...

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Bibliographic Details
Main Authors: Rossi, Francesca, Geiszler, Philippine C., Meng, Weina, Barron, Matthew, Prior, Malcolm, Herd-Smith, Anna, Loreto, Andrea, Yanez Lopez, Maria, Faas, Henryk, Pardon, Marie-Christine, Conforti, Laura
Format: Article
Language:English
Published: Elsevier 2018
Subjects:
Alzheimer’s disease (AD)
htau
NMNAT1
NAD
food burrowing
MRS
Online Access:https://eprints.nottingham.ac.uk/48415/

Internet

https://eprints.nottingham.ac.uk/48415/

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