Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment

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Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment

The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using a new paradigm of mechanistic assays. Under the CiPA paradigm, the relative risk of drug-induced Torsade de Pointes (TdP) is assessed using an in silico model of...

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Bibliographic Details
Main Authors:	Chang, Kelly, Dutta, Sara, Mirams, Gary R., Beattie, Kylie, Sheng, Jiansong, Tran, Phu N., Wu, Min, Wu, Wendy W., Colatsky, Thomas, Strauss, David G., Li, Zhihua
Format:	Article
Published:	Frontiers Media 2017
Subjects:	Uncertainty quantification; Experimental variability; Cardiac electrophysiology; Action potential; Torsade de Pointes; Ion channel; Pharmacology; Computational modeling
Online Access:	https://eprints.nottingham.ac.uk/48312/

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