Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment

Uncertainty quantification reveals the importance of data variability and experimental design considerations for in silico proarrhythmia risk assessment

The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a global initiative intended to improve drug proarrhythmia risk assessment using a new paradigm of mechanistic assays. Under the CiPA paradigm, the relative risk of drug-induced Torsade de Pointes (TdP) is assessed using an in silico model of...

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Bibliographic Details
Main Authors: Chang, Kelly, Dutta, Sara, Mirams, Gary R., Beattie, Kylie, Sheng, Jiansong, Tran, Phu N., Wu, Min, Wu, Wendy W., Colatsky, Thomas, Strauss, David G., Li, Zhihua
Format: Article
Published: Frontiers Media 2017
Subjects:
Uncertainty quantification; Experimental variability; Cardiac electrophysiology; Action potential; Torsade de Pointes; Ion channel; Pharmacology; Computational modeling
Online Access:https://eprints.nottingham.ac.uk/48312/

Internet

https://eprints.nottingham.ac.uk/48312/

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