Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator
In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution...
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| Format: | Article |
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Royal Society of Chemistry
2015
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| Online Access: | https://eprints.nottingham.ac.uk/48294/ |
| _version_ | 1848797733390909440 |
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| author | Marlow, Maria Al-Ameedee, Mohammed Smith, Thomas Wheeler, Simon Stocks, Michael J. |
| author_facet | Marlow, Maria Al-Ameedee, Mohammed Smith, Thomas Wheeler, Simon Stocks, Michael J. |
| author_sort | Marlow, Maria |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications. |
| first_indexed | 2025-11-14T20:08:34Z |
| format | Article |
| id | nottingham-48294 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:08:34Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-482942020-05-04T17:01:58Z https://eprints.nottingham.ac.uk/48294/ Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator Marlow, Maria Al-Ameedee, Mohammed Smith, Thomas Wheeler, Simon Stocks, Michael J. In this study we demonstrate that linifanib, a multi-targeted receptor tyrosine kinase inhibitor, with a key urea containing pharmacophore, self-assembles into a hydrogel in the presence of low amounts of solvent. We demonstrate the role of the urea functional group and that of fluorine substitution on the adjacent aromatic ring in promoting self-assembly. We have also shown that linifanib has superior mechanical strength to two structurally related analogues and hence increased potential for localisation at an injection site for drug delivery applications. Royal Society of Chemistry 2015-02-27 Article PeerReviewed Marlow, Maria, Al-Ameedee, Mohammed, Smith, Thomas, Wheeler, Simon and Stocks, Michael J. (2015) Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator. Chemical Communications, 51 . pp. 6384-6387. ISSN 1364-548X http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC00454C#!divAbstract doi:10.1039/c5cc00454c doi:10.1039/c5cc00454c |
| spellingShingle | Marlow, Maria Al-Ameedee, Mohammed Smith, Thomas Wheeler, Simon Stocks, Michael J. Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| title | Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| title_full | Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| title_fullStr | Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| title_full_unstemmed | Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| title_short | Linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| title_sort | linifanib – a multi-targeted receptor tyrosine kinase inhibitor and a low molecular weight gelator |
| url | https://eprints.nottingham.ac.uk/48294/ https://eprints.nottingham.ac.uk/48294/ https://eprints.nottingham.ac.uk/48294/ |