Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

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Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator

Drug-induced Torsades de Pointes (TdP) arrhythmia is of major interest in predictive toxicology. Drugs which cause TdP block the hERG cardiac potassium channel. However, not all drugs that block hERG cause TdP. As such, further understanding of the mechanistic route to TdP is needed. Early afterdepo...

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Bibliographic Details
Main Authors:	McMillan, Beth, Gavaghan, David J., Mirams, Gary R.
Format:	Article
Published:	Royal Society of Chemistry 2017
Online Access:	https://eprints.nottingham.ac.uk/48116/

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