Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator
Drug-induced Torsades de Pointes (TdP) arrhythmia is of major interest in predictive toxicology. Drugs which cause TdP block the hERG cardiac potassium channel. However, not all drugs that block hERG cause TdP. As such, further understanding of the mechanistic route to TdP is needed. Early afterdepo...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Published: |
Royal Society of Chemistry
2017
|
| Online Access: | https://eprints.nottingham.ac.uk/48116/ |