Antimicrobials and antimicrobial resistance
Drug discovery and development is becoming increasingly harder due to scientific bottlenecks, increased regulation from approval bodies and economic circumstance. Using unusual approaches to drug discovery can fast-track the production of new antimicrobials, as is the case with drug repurposing. The...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English English |
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2017
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| Online Access: | https://eprints.nottingham.ac.uk/48053/ |
| _version_ | 1848797679952330752 |
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| author | Smith, Frances |
| author_facet | Smith, Frances |
| author_sort | Smith, Frances |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Drug discovery and development is becoming increasingly harder due to scientific bottlenecks, increased regulation from approval bodies and economic circumstance. Using unusual approaches to drug discovery can fast-track the production of new antimicrobials, as is the case with drug repurposing. There is a strong need for antimicrobial agents that bacteria can’t develop resistance to and the best way to address this is by developing drugs that do not create a strong selection for resistance. Antivirulence drugs are ideal in this respect as they do not target essential biological processes. It is naïve, however, to assume that bacteria will never develop resistance to any of the antibiotics they are presented with. Careful control over the use of antibiotics should be employed to prevent the development and spread of resistance if we are to avoid the upcoming antibiotic apocalypse. |
| first_indexed | 2025-11-14T20:07:43Z |
| format | Thesis (University of Nottingham only) |
| id | nottingham-48053 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T20:07:43Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-480532025-02-28T13:55:17Z https://eprints.nottingham.ac.uk/48053/ Antimicrobials and antimicrobial resistance Smith, Frances Drug discovery and development is becoming increasingly harder due to scientific bottlenecks, increased regulation from approval bodies and economic circumstance. Using unusual approaches to drug discovery can fast-track the production of new antimicrobials, as is the case with drug repurposing. There is a strong need for antimicrobial agents that bacteria can’t develop resistance to and the best way to address this is by developing drugs that do not create a strong selection for resistance. Antivirulence drugs are ideal in this respect as they do not target essential biological processes. It is naïve, however, to assume that bacteria will never develop resistance to any of the antibiotics they are presented with. Careful control over the use of antibiotics should be employed to prevent the development and spread of resistance if we are to avoid the upcoming antibiotic apocalypse. 2017-12-12 Thesis (University of Nottingham only) NonPeerReviewed application/pdf en arr https://eprints.nottingham.ac.uk/48053/1/Smith_Frances_MResThesis_FinalandRevised_Confidential.pdf application/pdf en arr https://eprints.nottingham.ac.uk/48053/2/Smith_Frances_MResThesis_FinalandRevised_ConfidentialRemoved.pdf Smith, Frances (2017) Antimicrobials and antimicrobial resistance. MRes thesis, University of Nottingham. Antimicrobial resistance molecular microbiology drug screening |
| spellingShingle | Antimicrobial resistance molecular microbiology drug screening Smith, Frances Antimicrobials and antimicrobial resistance |
| title | Antimicrobials and antimicrobial resistance |
| title_full | Antimicrobials and antimicrobial resistance |
| title_fullStr | Antimicrobials and antimicrobial resistance |
| title_full_unstemmed | Antimicrobials and antimicrobial resistance |
| title_short | Antimicrobials and antimicrobial resistance |
| title_sort | antimicrobials and antimicrobial resistance |
| topic | Antimicrobial resistance molecular microbiology drug screening |
| url | https://eprints.nottingham.ac.uk/48053/ |