MYC regulation of Glutamine-Proline regulatory axis is key in Luminal B breast cancer

QR Code

MYC regulation of Glutamine-Proline regulatory axis is key in Luminal B breast cancer

Background: Altered cellular metabolism is a hallmark of cancer and some are reliant on Glutamine for sustained proliferation and survival. We hypothesise that the Glutamine-Proline regulatory axis has a key role in Breast cancer (BC) in the highly proliferative classes. Methods: Glutaminase (GLS),...

Full description

Bibliographic Details
Main Authors:	Craze, Madeleine L., Cheung, Hayley, Jewa, Natasha, Coimbra, Nuno D.M., Soria, Daniele, El-Ansari, Rokaya, Aleskandarany, Mohammed A., Cheng, Kiu Wai, Diez-Rodriguez, Maria, Nolan, Christopher C., Ellis, Ian O., Rakha, Emad, Green, Andrew R.
Format:	Article
Published:	Cancer Research UK 2017
Subjects:	metabolism breast cancer prognosis Luminal B glutamine proline
Online Access:	https://eprints.nottingham.ac.uk/47502/

Similar Items

Phenotypic characterization of breast cancer: the role of CDC42
by: Chrysanthou, Eleni, et al.
Published: (2017)

Altered glutamine metabolism in breast cancer: subtype dependencies and alternative adaptations
by: El Ansari, Rokaya, et al.
Published: (2017)

Enhancement of enzymatic properties of T1 lipase by saturation mutagenesis at glutamine 114
by: Ab. Wahab, Roswanira
Published: (2012)

The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours
by: El Ansari, Rokaya, et al.
Published: (2018)

Glutamine supplementation in cystic fibrosis: a randomized placebo-controlled trial
by: Forrester, Doug L., et al.
Published: (2015)

Oral supplementations with free and dipeptide forms of L-glutamine in endotoxemic mice: effects on muscle glutamine-glutathione axis and heat shock proteins
by: Cruzat, Vinicius, et al.
Published: (2014)

Luminance adaptive biomarker detection in digital pathology images
by: Liu, Jingxin, et al.
Published: (2016)

Exogenous proline significantly affects the plant growth and nitrogen assimilation enzymes activities in rice (Oryza sativa) under salt stress
by: Teh, Chui Yao, et al.
Published: (2016)

The multifunctional solute carrier 3A2 (SLC3A2) confers a poor prognosis in the highly proliferative breast cancer subtypes
by: El Ansari, Rokaya, et al.
Published: (2018)

Effects of dietary supplementation of glutamine and glutamic acid on performance and stress response to high temperature in broiler chickens
by: Omolayo, Olubodun Joshua
Published: (2015)

Cue combination of colour and luminance in edge detection
by: Sharman, Rebecca J.
Published: (2014)

Current issues with luminal subtype classification in terms of prediction of benefit from endocrine therapy in early breast cancer
by: Alfarsi, Lutfi, et al.
Published: (2018)

Development of a clinically relevant subclassification of luminal breast cancer related to response to endocrine therapy
by: Alfarsi, Lutfi
Published: (2020)

Amino acid transporters in breast cancer: promising prognostic markers and emerging targets across molecular subtypes
by: El Ansari, Rokaya
Published: (2020)

An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation
by: Candido Dos Reis, Francisco J., et al.
Published: (2017)

Ki67 expression in invasive breast cancer: the use of tissue microarrays compared with whole tissue sections
by: Muftah, Abir A., et al.
Published: (2017)

Isolation and characterization of a luminescent bacterium Vibrio SP. isolated MZ with potential application for biomonitoring of hydrocarbon biodegradation
by: Zahaba, Maryam
Published: (2013)

Prognostic significance of Glutamine-Related Solute Carriers in luminal breast cancer
by: Erkan, Busra
Published: (2025)

Rho-GTPase activating protein 18: a biomarker associated with good prognosis in invasive breast cancer
by: Aleskandarany, Mohammed A., et al.
Published: (2017)

Investigating the effects of drug combinations and loss of the PRH/Hhex oncoprotein in CCA cells
by: Martin, Grace
Published: (2025)

Prognostic indicators for naïve canine non-indolent T-cell lymphoma treated with combination lomustine, vincristine, procarbazine and prednisolone chemotherapy
by: Blaxill, J., et al.
Published: (2021)

FOXP1 expression correlates with better prognosis in invasive breast cancer including the ER-positive luminal subtype
by: Joseph, C., et al.
Published: (2017)

Order effects when using Hopkinson’s multiple criterion scale of discomfort due to glare
by: Kent, Michael G., et al.
Published: (2018)

MRI assessment on the impact of a low FODMAP diet on the gastrointestinal tract
by: Krishnasamy, Shanthi
Published: (2019)

Mathematical modelling of rod photoreceptor metabolism
by: Kunpasuruang, Wannapa
Published: (2009)

Amino acid supplementation and impact on immune function in the context of exercise
by: Cruzat, Vinicius, et al.
Published: (2014)

Mediator complex (MED) 7: a biomarker associated with good prognosis in invasive breast cancer, especially ER+ luminal subtypes
by: Joseph, Chitra, et al.
Published: (2018)

The significance of tumour microarchitectural features in breast cancer prognosis: a digital image analysis
by: Roxanis, I., et al.
Published: (2018)

Glutathione and glutamate in schizophrenia: a 7T MRS study
by: Kumar, Jyothika, et al.
Published: (2018)

Canine idiopathic chronic hepatitis
by: Bexfield, Nicholas
Published: (2017)

Expression of β-catenin, Ki67 and stroma percentage in colorectal cancer
by: Suanno, Cristina
Published: (2021)

Hepatic elastin content is predictive of adverse outcome in advanced fibrotic liver disease
by: Kendall, Timothy, et al.
Published: (2018)

Exploring the role of tumour microenvironment in the behaviour of breast ductal carcinoma in situ
by: Toss, Michael Salah Shawky
Published: (2020)

Understanding light in lightweight fabric (ETFE foil) structures through field studies
by: Lau, Benson, et al.
Published: (2016)

Clinical and biological roles of Kelch-like family member 7 in breast cancer: a marker of poor prognosis
by: Kurozumi, Sasagu, et al.
Published: (2018)

Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients
by: Heslin, M., et al.
Published: (2016)

Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease
by: Inns, Joseph, et al.
Published: (2015)

Preparing for the worst while hoping for the best: the relevance of hope in the heart failure illness trajectory
by: Davidson, Patricia, et al.
Published: (2007)

A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink
by: Crooks, Colin J., et al.
Published: (2018)

The function of MYC in youth development in Malaysia
by: Abdullah, Haslinda, et al.
Published: (2013)