S52 Suberanilohydroxamic acid (SAHA) inhibits collagen deposition in a transforming growth factor β1-driven precision cut lung slice (PCLS) model of pulmonary fibrosis

Introduction and objectives Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive interstitial lung disease that is refractory to current treatment options. Transforming growth factor (TGF)-β1 is a key pro-fibrotic cytokine that plays a crucial role in IPF pathogenesis. Our group previously...

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Bibliographic Details
Main Authors: Brand, Oliver J., Pasini, Alice, Habgood, Antony, Knox, Alan J., Jenkins, Gisli, Pang, Linhua
Format: Article
Published: BMJ Publishing Group 2016
Online Access:https://eprints.nottingham.ac.uk/47500/