Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

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Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoids with lipids can substantially increase their intestinal lymphatic transport in rats. C...

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Bibliographic Details
Main Authors:	Zgair, Atheer, Lee, Jong Bong, Wong, Jonathan Chi Man, Taha, Dhiaa A., Aram, Jehan, Virgilio, Daisy Di, McArthur, Andrew G., Cheng, Yu-Kit, Hennig, Ivo M., Barrett, David A., Fischer, Peter M., Constantinescu, Cris S., Gershkovich, Pavel
Format:	Article
Published:	Nature Publishing Group 2017
Subjects:	Autoimmune diseases Lymphatic system Translational research
Online Access:	https://eprints.nottingham.ac.uk/47445/

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