Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation

Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) have well documented immunomodulatory effects in vitro, but not following oral administration in humans. Here we show that oral co-administration of cannabinoids with lipids can substantially increase their intestinal lymphatic transport in rats. C...

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Bibliographic Details
Main Authors: Zgair, Atheer, Lee, Jong Bong, Wong, Jonathan Chi Man, Taha, Dhiaa A., Aram, Jehan, Virgilio, Daisy Di, McArthur, Andrew G., Cheng, Yu-Kit, Hennig, Ivo M., Barrett, David A., Fischer, Peter M., Constantinescu, Cris S., Gershkovich, Pavel
Format: Article
Published: Nature Publishing Group 2017
Subjects:
Autoimmune diseases
Lymphatic system
Translational research
Online Access:https://eprints.nottingham.ac.uk/47445/

Internet

https://eprints.nottingham.ac.uk/47445/

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