Stroke in women — from evidence to inequalities

Stroke is the second largest cause of disability-adjusted life-years lost worldwide. The prevalence of stroke in women is predicted to rise rapidly, owing to the increasing average age of the global female population. Vascular risk factors differ between women and men in terms of prevalence, and evi...

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Main Authors: Cordonnier, Charlotte, Sprigg, Nikola, Sandset, Else Charlotte, Pavlovic, Aleksandra, Sunnerhagen, Katharina S., Caso, Valeria, Christensen, Hanne
Format: Article
Published: Nature Publishing Group 2017
Subjects:
Online Access:https://eprints.nottingham.ac.uk/47042/
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author Cordonnier, Charlotte
Sprigg, Nikola
Sandset, Else Charlotte
Pavlovic, Aleksandra
Sunnerhagen, Katharina S.
Caso, Valeria
Christensen, Hanne
author_facet Cordonnier, Charlotte
Sprigg, Nikola
Sandset, Else Charlotte
Pavlovic, Aleksandra
Sunnerhagen, Katharina S.
Caso, Valeria
Christensen, Hanne
author_sort Cordonnier, Charlotte
building Nottingham Research Data Repository
collection Online Access
description Stroke is the second largest cause of disability-adjusted life-years lost worldwide. The prevalence of stroke in women is predicted to rise rapidly, owing to the increasing average age of the global female population. Vascular risk factors differ between women and men in terms of prevalence, and evidence increasingly supports the clinical importance of sex differences in stroke. The influence of some risk factors for stroke — including diabetes mellitus and atrial fibrillation — are stronger in women, and hypertensive disorders of pregnancy also affect the risk of stroke decades after pregnancy. However, in an era of evidence-based medicine, women are notably under-represented in clinical trials — despite governmental actions highlighting the need to include both men and women in clinical trials — resulting in a reduced generalizability of study results to women. The aim of this Review is to highlight new insights into specificities of stroke in women, to plan future research priorities, and to influence public health policies to decrease the worldwide burden of stroke in women.
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spelling nottingham-470422020-05-04T18:56:09Z https://eprints.nottingham.ac.uk/47042/ Stroke in women — from evidence to inequalities Cordonnier, Charlotte Sprigg, Nikola Sandset, Else Charlotte Pavlovic, Aleksandra Sunnerhagen, Katharina S. Caso, Valeria Christensen, Hanne Stroke is the second largest cause of disability-adjusted life-years lost worldwide. The prevalence of stroke in women is predicted to rise rapidly, owing to the increasing average age of the global female population. Vascular risk factors differ between women and men in terms of prevalence, and evidence increasingly supports the clinical importance of sex differences in stroke. The influence of some risk factors for stroke — including diabetes mellitus and atrial fibrillation — are stronger in women, and hypertensive disorders of pregnancy also affect the risk of stroke decades after pregnancy. However, in an era of evidence-based medicine, women are notably under-represented in clinical trials — despite governmental actions highlighting the need to include both men and women in clinical trials — resulting in a reduced generalizability of study results to women. The aim of this Review is to highlight new insights into specificities of stroke in women, to plan future research priorities, and to influence public health policies to decrease the worldwide burden of stroke in women. Nature Publishing Group 2017-07-21 Article PeerReviewed Cordonnier, Charlotte, Sprigg, Nikola, Sandset, Else Charlotte, Pavlovic, Aleksandra, Sunnerhagen, Katharina S., Caso, Valeria and Christensen, Hanne (2017) Stroke in women — from evidence to inequalities. Nature Reviews Neurology, 13 (9). pp. 521-532. ISSN 1759-4766 Health services Medical imaging Risk factors Stroke http://www.nature.com/nrneurol/journal/v13/n9/full/nrneurol.2017.95.html doi:10.1038/nrneurol.2017.95 doi:10.1038/nrneurol.2017.95
spellingShingle Health services
Medical imaging
Risk factors
Stroke
Cordonnier, Charlotte
Sprigg, Nikola
Sandset, Else Charlotte
Pavlovic, Aleksandra
Sunnerhagen, Katharina S.
Caso, Valeria
Christensen, Hanne
Stroke in women — from evidence to inequalities
title Stroke in women — from evidence to inequalities
title_full Stroke in women — from evidence to inequalities
title_fullStr Stroke in women — from evidence to inequalities
title_full_unstemmed Stroke in women — from evidence to inequalities
title_short Stroke in women — from evidence to inequalities
title_sort stroke in women — from evidence to inequalities
topic Health services
Medical imaging
Risk factors
Stroke
url https://eprints.nottingham.ac.uk/47042/
https://eprints.nottingham.ac.uk/47042/
https://eprints.nottingham.ac.uk/47042/