The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

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The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke

Background Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. Methods We prospectively recruited pa...

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Bibliographic Details
Main Authors:	Makin, Stephen D.J., Doubal, Fergus, Quinn, Terence J., Bath, Philip M.W., Dennis, Martin S., Wardlaw, Joanna M.
Format:	Article
Published:	SAGE 2017
Subjects:	Stroke Randomised trial Sample size Power calculation Lacunar Cognition Dependency Outcome
Online Access:	https://eprints.nottingham.ac.uk/46990/

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