The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke
Background Endpoints that are commonly used in trials of moderate/severe stroke may be less frequent in patients with minor, non-disabling stroke thus inflating sample sizes. We tested whether trial efficiency might be improved with composite endpoints. Methods We prospectively recruited pa...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
SAGE
2017
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/46990/ |