Development of a series of bis-triazoles as G-quadruplex ligands

QR Code

Development of a series of bis-triazoles as G-quadruplex ligands

Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells. Targeting telomere maintenance mechanisms could potentially...

Full description

Bibliographic Details
Main Authors:	Saleh, Maysaa, Laughton, Charles A., Bradshaw, Tracey D., Moody, Christopher J.
Format:	Article
Published:	Royal Society of Chemistry 2017
Online Access:	https://eprints.nottingham.ac.uk/46933/

Similar Items

RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells
by: Lagah, Sunil, et al.
Published: (2014)

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs
by: Hirt, Bartholomäus V., et al.
Published: (2014)

Drug-targetting of duplex and quadruplex DNA
by: Gavathiotis, Evripidis
Published: (2002)

Comparison Of Fab And Scfv Phage Display Efficiency: Application Of Best Format For The Development Of A Novel Dna G-Quadruplex Based Immunoassay
by: Loh, Qiuting
Published: (2015)

G-quadruplex microspheres-based optical RNA biosensor for arthropod-borne virus pathogen detection: A proof-of-concept with dengue serotype 2
by: Jamaluddin, Nur Diyana, et al.
Published: (2021)

3,5-Bis(4-hydroxyphenyl)-4H-1,2,4-triazol-4-amine monohydrate
by: Silong, Sidik, et al.
Published: (2010)

Photophysical and Photochemical Studies of Tricarbonyl Rhenium(I) N-Heterocyclic Carbene Complexes Containing Azide and Triazolate Ligands
by: Simpson, Peter V., et al.
Published: (2016)

A new binding geometry for an ortho-xylylene-linked bis(NHC)cyclophane: a ruthenium(II) complex with a chelating (g1-NHC)2:g6-arene ligand
by: Baker, M., et al.
Published: (2010)

Crystal structure of tetraaquabis(3,5-diamino- 4H-1,2,4-triazol-1-ium)cobalt(II) bis[bis(pyridine-2,6-dicarboxylato)- cobaltate(II)] dihydrate
by: Johnson, Atim, et al.
Published: (2015)

Synthesis of triazole-linked morpholino oligonucleotides via Cu1 catalysed cycloaddition
by: Palframan, Matthew J., et al.
Published: (2016)

One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4triazol-5(3)-amines) and their tautomerism
by: Phei, Felicia Lin Lim, et al.
Published: (2018)

One-pot, microwave-assisted synthesis of polymethylene-bridged bis(1H-1,2,4-triazol-5(3)-amines) and their tautomerism
by: Lim, F., et al.
Published: (2018)

Silver and Palladium Complexes of a Bis(benzimidazolin-2-ylidene)pyridine Pincer Ligand
by: Brown, David, et al.
Published: (2009)

GPCRs through the keyhole: the role of protein flexibility in ligand binding to β-adrenoceptors
by: Emtage, Abigail L., et al.
Published: (2016)

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery
by: Santos, Marilla S., et al.
Published: (2018)

Application of dye-ligands affinity adsorbent in capturing of rabbit immunoglobulin G
by: Wongchuphan, Rattana, et al.
Published: (2009)

Crystal and molecular structures of a binuclear mixed ligand complex of silver(I) with thiocyanate and 1H-1,2,4-triazole-5(4H)-thione
by: Kreaunakpan, Janjira, et al.
Published: (2020)

Nickel complexes of a bis(benzimidazolin-2-ylidene)pyridine pincer ligand with four- and five-coordinate geometries
by: Brown, David, et al.
Published: (2011)

2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole is a ligand and shows species-specific partial agonism of the Aryl Hydrocarbon Receptor
by: Bazzi, Rana, et al.
Published: (2009)

Effect of polymer shielding on elution of G3PDH bound to dye-ligand adsorbent
by: Ling, Tau Chuan, et al.
Published: (2006)

Crystal Structures And Analysis Of 1,2,4 Triazole And Pyrazole Compounds
by: Goh , Jia Hao
Published: (2011)

3-Phenyl-1H-1,2,4-triazol-5-amine-5-phenyl-1H-1,2,4-triazol-3-amine (1/1).
by: Dolzhenko, Anton, et al.
Published: (2009)

The Impact of Job Satisfaction and Job Characteristics on Turnover Intention in Palestine
by: Yaghi, Maysaa Saleh Mahmoud
Published: (2011)

Synthesis, Solid-state Structures, Solution Behaviour and Catalysis Studies of Nickel Complexes of Bis(benzimidazolin-2-ylidene)pyridine Pincer Ligands
by: McGee, Karen, et al.
Published: (2012)

Negatively charged Ir(III) cyclometalated complexes containing a chelating bis-tetrazolato ligand: Synthesis, photophysics and the study of reactivity with electrophiles
by: Fiorini, V., et al.
Published: (2016)

Synthesis, Characterization and Antioxidant Activity of 1, 2, 4-Triazole Schiff Base
by: Teh, Chor Chin
Published: (2016)

Human G6PD variant structural studies: Elucidating the molecular basis of human G6PD deficiency
by: Alakbaree, Maysaa, et al.
Published: (2022)

In vitro antitumor effects of AHR ligands aminoflavone (AFP 464) and benzothiazole (5F 203) in human renal carcinoma cells
by: Luzzani, Gabriela A., et al.
Published: (2017)

Synthesis, Characterisation And Cytotoxicity Study Of Some New 1,2,4-Triazole Derivatives
by: Mohsin Slaihim, Mukhlif
Published: (2017)

High temperature liquid chromatography of triazole fungicides on polybutadiene-coated zirconia stationary phase
by: Sanagi, M. Marsin, et al.
Published: (2004)

Comparison among four triazole fungicides on growth and development of sheath blight of rice pathogen Rhizoctonia solani Kühn AG1-1A
by: Datta, Sambit, et al.
Published: (2016)

Modeling of multiband/wideband stack series array antenna configuration for 5G application
by: Osman, Abdinasir Suleiman, et al.
Published: (2016)

1-Anilino-5-methyl-1H-1,2,3-triazole-4-carbaldehyde
by: Cunha, Anna C., et al.
Published: (2016)

An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazoles
by: Dolzhenko, Anton, et al.
Published: (2009)

3-Pyridin-2-yl-1H-1,2,4-triazol-5-amine.
by: Dolzhenko, Anton, et al.
Published: (2009)

Synthesis, characterization and antioxidant activity of 1,2,4-triazole and its Schiff base derivatives
by: Wong, Wen Li
Published: (2023)

Complex formation and enantioselectivity studies of triazole fungicide and organophosphorus pesticide enantiomers using capillary electrophoresis
by: Wan Ibrahim, Wan Aini, et al.
Published: (2008)

Synthesis, characterization and structure determination of novel chromium hexacarbonyl derivatives via substitution with various group 15 complex ligands (L) where L = ethylenebis diphenyl-arsine, P-bromophenyl diphenylphosphane, bis (diphenylphosphino) hexane, bis (diphenylphosphino) pentane, and triphenylarsine
by: Muhammad Azhar , Mohd Yunus
Published: (2012)

The development candidate therapeutic and diagnostic ligands for prion diseases
by: Workman, R.W.
Published: (2018)

Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A
by: Altamimi, Abdul Malek S., et al.
Published: (2018)