Development of a series of bis-triazoles as G-quadruplex ligands
Maintenance of telomeres – specialized complexes that protect the ends of chromosomes – is provided by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells, but absent in most normal cells. Targeting telomere maintenance mechanisms could potentially...
| Main Authors: | , , , |
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| Format: | Article |
| Published: |
Royal Society of Chemistry
2017
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| Online Access: | https://eprints.nottingham.ac.uk/46933/ |