A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)

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A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)

Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. Misfolding, intracellular aggregation, and ligand-independent signaling by mutant TNFR1 are central to disease pathophysiology....

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Bibliographic Details
Main Authors:	Negm, Ola H., Mannsperger, Heiko A., McDermott, Elizabeth M., Drewe, Elizabeth, Powell, Richard J., Todd, Ian, Fairclough, Lucy C., Tighe, Patrick J.
Format:	Article
Published:	Wiley 2014
Subjects:	Autoinflammation; Protein microarray; Signalome; TNF receptor 1; TRAPS
Online Access:	https://eprints.nottingham.ac.uk/46896/

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