A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)
Mutations in TNFRSF1A encoding TNF receptor 1 (TNFR1) cause the autosomal dominant TNF receptor-associated periodic syndrome (TRAPS): a systemic autoinflammatory disorder. Misfolding, intracellular aggregation, and ligand-independent signaling by mutant TNFR1 are central to disease pathophysiology....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Published: |
Wiley
2014
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/46896/ |