A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing

QR Code

A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing

TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the disease mechanism. Our aim was to identify drugs...

Full description

Bibliographic Details
Main Authors:	Todd, Ian, Negm, Ola H., Reps, Jenna, Radford, Paul, Figueredo, Grazziela P., McDermott, Elizabeth M., Drewe, Elizabeth, Powell, Richard J., Bainbridge, Susan, Hamed, Mohamed, Crouch, Sharon, Garibaldi, Jon, St-Gallay, Steve, Fairclough, Lucy C., Tighe, Patrick J.
Format:	Article
Published:	Elsevier 2017
Subjects:	Drug repurposing Reverse-phase protein micro-array Signalome TNF receptor associated periodic syndrome Fluoroquinolone Anti-inflammatory
Online Access:	https://eprints.nottingham.ac.uk/46737/

Similar Items

A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS)
by: Negm, Ola H., et al.
Published: (2014)

A phase 3, open-label, randomized trial to evaluate the safety and efficacy of levofloxacin inhalation solution (APT-1026) versus tobramycin inhalation solution in stable cystic fibrosis patients
by: Elborn, J. Stuart, et al.
Published: (2015)

A phase 3, multi-center, multinational, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of levofloxacin inhalation solution (APT-1026) in stable cystic fibrosis patients
by: Flume, Patrick, et al.
Published: (2016)

The future of multiple sclerosis treatments
by: Coclitu, Catalina, et al.
Published: (2016)

Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics
by: Huckle, Anthony W., et al.
Published: (2018)

Topics in the mathematical modelling of nanotoxicology
by: Jones, Zofia
Published: (2012)

A Germline MTOR Mutation in Aboriginal Australian Siblings with Intellectual Disability, Dysmorphism, Macrocephaly, and Small Thoraces
by: Baynam, G., et al.
Published: (2015)

Low-dose salinomycin induces anti-leukemic responses in AML and MLL
by: Roulston, Gary D.R., et al.
Published: (2016)

NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time
by: Abdullah, Zuraidah, et al.
Published: (2014)

Antimicrobial resistance (AMR) nanomachines: mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation
by: Phillips-Jones, Mary K., et al.
Published: (2018)

Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage
by: Abdullah, Zuraidah, et al.
Published: (2015)

Investigation of ATP-mediated interleukin-1 secretion in human decidua
by: Liu, Yaqiong
Published: (2018)

Separating chemotherapy-related developmental neurotoxicity from cytotoxicity in monolayer and neurosphere cultures of human fetal brain cells
by: Ivanov, Delyan P., et al.
Published: (2016)

Comparing stochastic differential equations and agent-based modelling and simulation for early-stage cancer
by: Figueredo, Grazziela P., et al.
Published: (2014)

Is there potential for repurposing statins as novel antimicrobials?
by: Hennessy, E., et al.
Published: (2016)

Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system
by: Abdullah, Zuraidah, et al.
Published: (2016)

Translating simulation approaches for immunology
by: Figueredo, Grazziela P.
Published: (2012)

Repurposeable Learning Objects Based on Teaching and Learning Styles
by: Kaur, Abtar, Prof Dr, et al.
Published: (2003)

Repurposing, integrating, and rating serious games as learning objects
by: Hendrix, M., et al.
Published: (2012)

Tumor necrosis factor receptor I blockade shows that TNF-dependent and independent mechanisms synergise in TNF receptor associated periodic syndrome
by: Fairclough, Lucy C., et al.
Published: (2015)

Repurposing rural technical vocational education and training in South Africa
by: Mancotywa, Yoliswa Lindelwa
Published: (2023)

Rediscovering and repurposing natural microbial macromolecules through computational approaches
by: Abdella, M. *, et al.
Published: (2020)

Detecting adverse drug reactions in the general practice healthcare database
by: Reps, Jenna Marie
Published: (2014)

Characterisation of CrN-NbN Superlattice Coatings, including their simulated wear debris, for total joint prosthesis bearing surface applications
by: Smith, Conor
Published: (2023)

Women waste collectors, recyclers and repurposers for circular economy: an ethnographic study
by: Rokis, Rohaiza
Published: (2020)

Veterinary communication skills and training in the United Kingdom and the United States of America
by: McDermott, Michael P.
Published: (2018)

Targeting inflammation in non-small cell lung cancer through drug repurposing
by: Rajasegaran, Thiviyadarshini, et al.
Published: (2023)

Defining a simulation strategy for cancer immunocompetence
by: Figueredo, Grazziela P., et al.
Published: (2010)

Investigating immune system aging: system dynamics and agent-based modeling
by: Figueredo, Grazziela P., et al.
Published: (2010)

Comparing System Dynamics and Agent-Based Simulation for tumour growth and its interactions with effector cells
by: Figueredo, Grazziela P., et al.
Published: (2011)

Performance analysis on the safety and automation system of a modified cutting machine: repurposing initiatives
by: Ahsana Aqilah Ahmad,, et al.
Published: (2024)

Lipid transfer proteins and the tuning of compartmental identity in the Golgi apparatus
by: McDermott, M., et al.
Published: (2016)

Incorporating spontaneous reporting system data to aid causal inference in longitudinal healthcare data
by: Reps, Jenna M., et al.
Published: (2014)

Identifying candidate risk factors for prescription drug side effects using causal contrast set mining
by: Reps, Jenna M., et al.
Published: (2015)

Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia
by: Kettyle, Laura M.J., et al.
Published: (2014)

Drug repurposing of clinically-approved drugs to target epithelial-mesenchymal transition using in silico analysis
by: Ong, Chun Hao
Published: (2021)

Discovery of Mycobacterium tuberculosis CYP121 new inhibitor via structure-based drug repurposing
by: El Moudaka, Tarek, et al.
Published: (2022)

The potential for repurposing α2-adrenoceptor agonists and noradrenaline uptake1 inhibitors in the management of septic shock
by: Benyamen, Julian
Published: (2024)

Fire protection provisions for pre-building codes shophouses repurposed into budget hotel: a Malaysian perspective
by: Dg Badariah Ag Ali,, et al.
Published: (2018)

Enhancing the productivity of pyramid solar still utilizing repurposed finishing pads as cost-effective porous material
by: Suraparaju, Subbarama Kousik, et al.
Published: (2024)