A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing

A signalome screening approach in the autoinflammatory disease TNF Receptor Associated Periodic Syndrome (TRAPS) highlights the anti-inflammatory properties of drugs for repurposing

TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the disease mechanism. Our aim was to identify drugs...

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Bibliographic Details
Main Authors: Todd, Ian, Negm, Ola H., Reps, Jenna, Radford, Paul, Figueredo, Grazziela P., McDermott, Elizabeth M., Drewe, Elizabeth, Powell, Richard J., Bainbridge, Susan, Hamed, Mohamed, Crouch, Sharon, Garibaldi, Jon, St-Gallay, Steve, Fairclough, Lucy C., Tighe, Patrick J.
Format: Article
Published: Elsevier 2017
Subjects:
Drug repurposing
Reverse-phase protein micro-array
Signalome
TNF receptor associated periodic syndrome
Fluoroquinolone
Anti-inflammatory
Online Access:https://eprints.nottingham.ac.uk/46737/

Internet

https://eprints.nottingham.ac.uk/46737/

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