A comparison of drug transport in pulmonary absorption models: isolated perfused rat lungs, respiratory epithelial cell lines and primary cell culture

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A comparison of drug transport in pulmonary absorption models: isolated perfused rat lungs, respiratory epithelial cell lines and primary cell culture

Purpose To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. Method The permeability of seven compounds selected to possess a range of lipophilicity was measured in two airway c...

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Bibliographic Details
Main Authors:	Bosquillon, Cynthia, Madlova, Michaela, Patel, Nilesh, Clear, Nicola, Forbes, Ben
Format:	Article
Published:	Springer 2017
Subjects:	16HBE14o-; biopharmaceutics; calu-3; inhalation; isolated perfused lungs (IPL); NHBE permeability; pulmonary
Online Access:	https://eprints.nottingham.ac.uk/46718/

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