A comparison of drug transport in pulmonary absorption models: isolated perfused rat lungs, respiratory epithelial cell lines and primary cell culture
Purpose To evaluate the ability of human airway epithelial cell layers and a simple rat isolated perfused lung (IPL) model to predict pulmonary drug absorption in rats in vivo. Method The permeability of seven compounds selected to possess a range of lipophilicity was measured in two airway c...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Springer
2017
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/46718/ |