Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy
A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.
Bibliographic Details
| Main Authors: |
Rawling, M.J.,
Storr, T.E.,
Bawazir, W.A.,
Cully, S.J.,
Lewis, W.,
Makki, M.S.I.T.,
Strutt, I.R.,
Jones, G.,
Hamza, D.,
Stockman, R.A. |
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| Format: | Article
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| Published: |
Royal Society of Chemistry
2015
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| Online Access: | https://eprints.nottingham.ac.uk/46643/
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