One-pot Cannizzaro cascade synthesis of ortho-Fused Cycloocta-2,5-dien-1-ones from 2-Bromo(hetero)aryl aldehydes

One-pot Cannizzaro cascade synthesis of ortho-Fused Cycloocta-2,5-dien-1-ones from 2-Bromo(hetero)aryl aldehydes

An intramolecular Cannizzaro-type hydride transfer to an in situ prepared allene enables the synthesis of orthofused 4-substituted cycloocta-2,5-dien-1-ones with unprecedented technical ease for an eight-ring carboannulation. Various derivatives could be obtained from commercially available (hetero)...

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Bibliographic Details
Main Authors: Burroughs, Laurence, Eccleshare, Lee, Ritchie, John, Kulkarni, Omkar, Lygo, Barry, Woodward, Simon, Lewis, William
Format: Article
Published: Wiley-VCH Verlag 2015
Subjects:
aldehydes; annulation; carbocycles; medium-ring compounds; synthetic methods
Online Access:https://eprints.nottingham.ac.uk/46633/

Internet

https://eprints.nottingham.ac.uk/46633/

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