SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis

SOX9 predicts progression towards cirrhosis in patients while its loss protects against liver fibrosis

Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis and downstream potential for tissue remodeling. However, less is known about the transcriptional regulation in vivo governing fibrotic matrix d...

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Bibliographic Details
Main Authors: Athwal, Varinder S., Pritchett, James, Llewellyn, Jessica, Martin, Katherine, Camacho, Elizabeth, Raza, Sayyid M.A., Phythian-Adams, Alexander, Birchall, Lindsay J., Mullan, Aoibheann F., Su, Kim, Pearmain, Laurence, Dolman, Grace, Zaitoun, Abed M., Friedman, Scott L., MacDonald, Andrew, Irving, William L., Guha, Indra N., Hanley, Neil A., Hanley, Karen Piper
Format: Article
Published: Wiley Open Access 2017
Subjects:
SOX9; YAP1; Liver fibrosis; Extracellular matrix; Hepatic stellate cells
Online Access:https://eprints.nottingham.ac.uk/46609/

Internet

https://eprints.nottingham.ac.uk/46609/

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