Asymmetric synthesis of pyrrolidine-containing chemical scaffolds via Tsuji-Trost allylation of N-tert-butanesulfinyl imines

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Asymmetric synthesis of pyrrolidine-containing chemical scaffolds via Tsuji-Trost allylation of N-tert-butanesulfinyl imines

A simple and efficient asymmetric synthesis of novel sp3 rich pyrrolidine chemical scaffolds over five steps starting from simple ketones is described. Key steps involve the use of tert-butanesulfinamide as a chiral auxiliary to perform an asymmetric Tsuji-Trost allylation, with subsequent cross-met...

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Bibliographic Details
Main Authors:	Dawood, Rafid S., Georgiou, Irene, Wilkie, Ross P., Lewis, William, Stockman, Robert A.
Format:	Article
Published:	Wiley-VCH Verlag 2017
Online Access:	https://eprints.nottingham.ac.uk/46526/

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