Asymmetric synthesis of pyrrolidine-containing chemical scaffolds via Tsuji-Trost allylation of N-tert-butanesulfinyl imines
A simple and efficient asymmetric synthesis of novel sp3 rich pyrrolidine chemical scaffolds over five steps starting from simple ketones is described. Key steps involve the use of tert-butanesulfinamide as a chiral auxiliary to perform an asymmetric Tsuji-Trost allylation, with subsequent cross-met...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
Wiley-VCH Verlag
2017
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| Online Access: | https://eprints.nottingham.ac.uk/46526/ |