Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

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Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is there...

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Bibliographic Details
Main Authors:	Mwenechanya, Roy, Kovarova, Julie, Dickens, Nicholas J., Mudaliar, Manikhandan, Herzyk, Pawel, Vicent, Isabel M., Weidt, Stefan K., Burgess, Karl E., Burchmore, Richard J.S., Pountain, Andrew W., Smith, Terry K., Creek, Darren J., Kim, Dong-Hyun, Lepesheva, Galina I., Barrett, Michael P.
Format:	Article
Published:	Public Library of Science 2017
Online Access:	https://eprints.nottingham.ac.uk/45552/

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