All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study
Background: Mortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population. Aim: To determine the overall survival in patients with cir...
| Main Authors: | , , , |
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| Format: | Article |
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Wiley
2012
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| Online Access: | https://eprints.nottingham.ac.uk/45119/ |
| _version_ | 1848797072930635776 |
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| author | Fleming, Kate M. Aithal, Guruprasad P. Card, Tim R. West, Joe |
| author_facet | Fleming, Kate M. Aithal, Guruprasad P. Card, Tim R. West, Joe |
| author_sort | Fleming, Kate M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Mortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population.
Aim: To determine the overall survival in patients with cirrhosis compared with the general population taking into account the effects of severity and aetiology of disease and comorbidity.
Methods: In a cohort study, we identified 4537 people with cirrhosis and a control cohort of 44 403 patients, matched by age, sex and general practice from the UK General Practice Research Database between June 1987 and April 2002.
Results: Patients with compensated cirrhosis had a nearly five-fold [hazard ratio (HR) 4.7, 95% confidence interval (CI) 4.4–5.0] increased risk of death, while those with decompensated cirrhosis had a near 10-fold (HR 9.7, 95% CI 8.9–10.6) increased risk compared with the general population. Alcoholic cirrhosis conferred a worse prognosis than non-alcohol-related cirrhosis both in the first year following diagnosis and subsequently.
Conclusion: Having a diagnosis of cirrhosis confers a substantial increased mortality risk compared with the general population, even for those with compensated disease, with 5-year survival between that seen for breast and colorectal cancer. |
| first_indexed | 2025-11-14T19:58:04Z |
| format | Article |
| id | nottingham-45119 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T19:58:04Z |
| publishDate | 2012 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-451192020-05-04T16:32:18Z https://eprints.nottingham.ac.uk/45119/ All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study Fleming, Kate M. Aithal, Guruprasad P. Card, Tim R. West, Joe Background: Mortality due to cirrhosis has tripled over the last 30 years in the UK. However, we lack adequate, contemporary, population-based estimates of the excess mortality patients who are at risk compared with the general population. Aim: To determine the overall survival in patients with cirrhosis compared with the general population taking into account the effects of severity and aetiology of disease and comorbidity. Methods: In a cohort study, we identified 4537 people with cirrhosis and a control cohort of 44 403 patients, matched by age, sex and general practice from the UK General Practice Research Database between June 1987 and April 2002. Results: Patients with compensated cirrhosis had a nearly five-fold [hazard ratio (HR) 4.7, 95% confidence interval (CI) 4.4–5.0] increased risk of death, while those with decompensated cirrhosis had a near 10-fold (HR 9.7, 95% CI 8.9–10.6) increased risk compared with the general population. Alcoholic cirrhosis conferred a worse prognosis than non-alcohol-related cirrhosis both in the first year following diagnosis and subsequently. Conclusion: Having a diagnosis of cirrhosis confers a substantial increased mortality risk compared with the general population, even for those with compensated disease, with 5-year survival between that seen for breast and colorectal cancer. Wiley 2012-01-03 Article PeerReviewed Fleming, Kate M., Aithal, Guruprasad P., Card, Tim R. and West, Joe (2012) All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study. Liver International, 32 (1). pp. 79-84. ISSN 1478-3231 http://onlinelibrary.wiley.com/doi/10.1111/j.1478-3231.2011.02517.x/abstract doi:10.1111/j.1478-3231.2011.02517.x doi:10.1111/j.1478-3231.2011.02517.x |
| spellingShingle | Fleming, Kate M. Aithal, Guruprasad P. Card, Tim R. West, Joe All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| title | All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| title_full | All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| title_fullStr | All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| title_full_unstemmed | All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| title_short | All-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| title_sort | all-cause mortality in people with cirrhosis compared with the general population: a population-based cohort study |
| url | https://eprints.nottingham.ac.uk/45119/ https://eprints.nottingham.ac.uk/45119/ https://eprints.nottingham.ac.uk/45119/ |