Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease

Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease

A number of genetic loci associate with early onset Alzheimer’s disease (EOAD), however the drivers of this disease remains enigmatic. Genome wide association and in-vivo modelling have shown that loss-of-function e.g. ABCA7, reduced levels of SIRT1, MEFF2C or increases levels of PTK2β confer risk o...

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Bibliographic Details
Main Authors: Boden, Kirsty A., Barber, Imelda S., Clement, Naomi, Patel, Tulsi, Guetta-Baranes, Tamar, Brookes, Keeley, Chappell, Sally, Craigon, Jim, Chapman, Natalie H., Morgan, Kevin, Seymour, Graham B., Bottley, Andrew
Format: Article
Published: IOS Press 2017
Subjects:
Epigenetics
Alzheimer’s disease
Methylation
Sporadic early onset
Online Access:https://eprints.nottingham.ac.uk/45002/

Internet

https://eprints.nottingham.ac.uk/45002/

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