Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

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Proteolytic properties of single-chain factor XII: a mechanism for triggering contact activation

When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact activation. These enzymes contribute to host-defense...

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Bibliographic Details
Main Authors:	Ivanov, Ivan, Matafonov, Anton, Sun, Mao-fu, Cheng, Qiufang, Dickeson, S. Kent, Verhamme, Ingrid M., Emsley, Jonas, Gailani, David
Format:	Article
Published:	American Society of Hematology 2017
Online Access:	https://eprints.nottingham.ac.uk/44922/

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