Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a glass of water (8 oz), particularly in the colon,...

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Bibliographic Details
Main Authors: Murray, Kathryn, Hoad, Caroline L., Mudie, Deanna M., Wright, Jeff, Heissam, Khaled, Abrehart, Nichola, Pritchard, Susan E., Al Atwah, Salem, Gowland, Penny A., Garnett, Martin C., Amidon, Greg E., Spiller, Robin C., Amidon, Gordon L., Marciani, Luca
Format: Article
Published: American Chemical Society 2017
Subjects:
Intestinal water
Bioperformance
Dissolution
Large bowel
MRI
Controlled release
Delayed release
Online Access:https://eprints.nottingham.ac.uk/44143/

Internet

https://eprints.nottingham.ac.uk/44143/

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