PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

QR Code

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz

Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding diseases. The [(o-chlorobenzylidene)amino]guanidines (Guanabenz and Sephin1) have...

Full description

Bibliographic Details
Main Authors:	Crespillo-Casado, Ana, Chambers, Joseph E., Fischer, Peter M., Marciniak, Stefan J., Ron, David
Other Authors:	Malhotra, Vivek
Format:	Article
Published:	eLife Sciences Publications 2017
Subjects:	Cricetulus griseus Protein synthesis Phosphorylation Chemical biology Drug action
Online Access:	https://eprints.nottingham.ac.uk/44064/

Similar Items

Computational re-design of Streptomyces griseus Chitinase C and analysis of biochemical, biophysical and antifungal properties of designed variants
by: Omolola, Oyeleye Ayokunmi
Published: (2021)

Unphosphorylated dimers are not required for the assembly of active STAT1 and STAT3 homo-and heterodimers
by: Krause, Sebastian C.
Published: (2023)

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B
by: Zyryanova, Alisa F., et al.
Published: (2018)

Defining the role of post-translational modification on the mismatch repair and meiotic crossover protein Mlh1
by: Fairbanks, Harriet
Published: (2023)

Visual crowding is unaffected by adaptation-induced spatial compression
by: Chambers, Alison L., et al.
Published: (2018)

Molecular dynamics simulation of the phosphorylation-induced conformational changes of a tau peptide fragment
by: Lyons, Albert, et al.
Published: (2014)

A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease
by: Barron, Matthew, et al.
Published: (2016)

Understanding the role of mitochondrial haemoglobin - an in silico approach
by: Katyal, Gunjan
Published: (2022)

Investigating a key autophagy protein-protein interaction and its modulation by phosphorylation and an ALS-related mutation
by: Brennan, Andrew
Published: (2019)

Exploring the effects of ageing, cancer, and exercise on skeletal muscle mitochondrial function
by: Smart, Thomas
Published: (2024)

The malignant phenotype in breast cancer is driven by eIF4A1-mediated changes in the translational landscape
by: Modelska, A., et al.
Published: (2015)

Pattern Visual Evoked Potential (VEP) is unaffected in the early stage of mild cognitive impairment
by: Lau, Chean Ling, et al.
Published: (2017)

Investigations of the DEAD-box helicase eIF4A
by: Phillips, Nicola Marie
Published: (2011)

Issues faced by unaffected men with a family history of prostate cancer: a multidisciplinary overview
by: Wakefield, C., et al.
Published: (2008)

Interleukin-7 signalling defects in naive CD4+ T cells of HIV patients with CD4+ T-cell deficiency onantiretroviral therapy are associated with T-cell activation and senescence
by: Tanaskovic, S., et al.
Published: (2014)

In vitro and in vivo enzymatic dephosphorylation of phytate in maize-soya bean meal diets for broiler chickens by phytase of Mitsuokella jalaludinii.
by: Lan, Gan Qiu, et al.
Published: (2010)

Targeting cytokine- and therapy-induced PIM1 activation in preclinical models of T-cell acute lymphoblastic leukemia and lymphoma
by: De Smedt, Renate, et al.
Published: (2020)

Exercise-induced immunosuppression: roles of reactive oxygen species and 5′-AMP-activated protein kinase dephosphorylation within immune cells
by: Moir, H., et al.
Published: (2010)

DEF6 is associated with the translational initiation regulating protein synthesis of eIF4E, 4E-T and PABP and colocalises with eIF4E and PABP in the immunological synapse
by: Alsayegh, Maha
Published: (2018)

Understanding the role of eIF4A in gene regulation in health and disease
by: Webb, Thomas E.
Published: (2012)

Aberrant post-translational protein modifications in the pathogenesis of alcohol-induced liver injury
by: Osna, Natalie, et al.
Published: (2016)

Modulation of mu-opioid receptor dynamics at the plasma membrane and its implications for signalling and trafficking
by: Underwood, Owen George
Published: (2024)

Abdominal muscle feedforward activation in patients with chronic low back pain is largely unaffected by 8 weeks of core stability training
by: Allison, Garry
Published: (2012)

Expression pattern and function of eIFE4 isoforms in planarian adult stem cells
by: Tuqan, Duniazad F
Published: (2011)

An assessment of the stimulation of rubber biosynthesis by eIF-5A proteins-enriched bacterial lysates
by: Yusof, Faridah, et al.
Published: (2006)

Development of an interactive teaching-learning technique of mathematics based on the EIF technique for the primary schools
by: Ahmad, Ab. Rahman, et al.
Published: (2004)

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: synthesis, structural and functional characterisation
by: Soukarieh, Fadi, et al.
Published: (2016)

eIF4A2 is a regulator of hypoxic translation and colorectal tumour cell survival
by: Bolland, Hannah
Published: (2020)

Disclosure of public-private partnership (PPP) voluntary information: case of Malaysian PPP projects
by: Musawa, Mubarak Shehu, et al.
Published: (2017)

Kinematic PPP-AR in Antarctic
by: Bezcioglu, M., et al.
Published: (2019)

Role of eIF4A proteins in miR-122 mediated Hepatitis C virus regulation
by: Ahmed, Choudhary-Shoaib
Published: (2017)

Investigating the role of eIF4A2 in the spatial regulation of metabolic adaptation to hypoxia in colorectal cancer
by: Thornton, Luke
Published: (2023)

Induction of endoplasmic reticulum stress pathway by green tea epigallocatechin-3-gallate (EGCG) in colorectal cancer cells: activation of PERK/p-eIF2α/ATF4 and IRE1α
by: Md Nesran, Zarith Nameyrra, et al.
Published: (2019)

PPP within the context of the procurement paradigm
by: Abdul Rashid, Khairuddin
Published: (2010)

Review and principles of PPP-RTK methods
by: Teunissen, Peter, et al.
Published: (2015)

Analysing the Zenith Tropospheric Delay estimates in on-line Precise Point Positioning (PPP) services and PPP software packages
by: Mendez Astudillo, Jorge, et al.
Published: (2018)

Investigating Performance of High-Rate GNSS-PPP and PPP-AR for Structural Health Monitoring: Dynamic Tests on Shake Table
by: Yigit, Cemal Ozer, et al.
Published: (2021)

Towards a common PPP framework for ASEAN
by: Abdul Rashid, Khairuddin
Published: (2018)

Implementation of the Malaysian Public Private Partnership (PPP)
by: Abdul Rashid, Khairuddin
Published: (2013)

PPP-RTK and inter-system biases: the ISB look-up table as a means to support multi-system PPP-RTK
by: Khodabandeh, Amir, et al.
Published: (2016)