PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding diseases. The [(o-chlorobenzylidene)amino]guanidines (Guanabenz and Sephin1) have...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Published: |
eLife Sciences Publications
2017
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| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/44064/ |