Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice

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Immunization with Toxoplasma gondii GRA17 deletion mutant induces partial protection and survival in challenged mice

Toxoplasmosis remains a world-threatening disease largely because of the lack of a fully effective vaccine. Here, we created a ΔGRA17 mutant by disrupting the virulence factor GRA17 using CRISPR-Cas9 method. Then, we tested whether ΔGRA17 tachyzoites can be used as a live-attenuated vaccine against...

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Bibliographic Details
Main Authors:	Wang, Jin-Lei, Elsheikha, Hany M., Zhu, Wei-Ning, Chen, Kai, Li, Ting-Ting, Yue, Dong-Mei, Zhang, Xiao-Xuan, Huang, Si-Yang, Zhu, Xing-Quan
Format:	Article
Published:	Frontiers Media 2017
Subjects:	Toxoplasma gondii immunization live-attenuated vaccine ΔGRA17 Th1/Th2 cytokines
Online Access:	https://eprints.nottingham.ac.uk/43930/

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